Carcinogenesis, Teratogenesis & Mutagenesis ›› 2006, Vol. 18 ›› Issue (4): 314-315.doi: 10.3969/j.issn.1004-616x.2006.04.016

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Expression of Tankyrase mRNA in the Malignant Transformation of Cells Induced by Crystalline Nickel Sulfide

WANG Min, LU Jia-chun   

  1. Institute of Chemical Carcinogenesis,Guangzhou Medical College,
  • Received:2006-01-10 Revised:2005-08-11 Online:2006-07-30 Published:2006-07-30
  • Contact: LU Jia-chun

Abstract: BACKGROUND&AIM: To study the expression of tankyrase in human bronchial epithelial malignantly transformed cells induced by crystalline nickel sulfide. MATERIAL AND METHODS: The method of reverse transcription-polymerase chain reaction(RT-PCR)was used to measure the expression of tankyrase mRNA in 16HBE and malignantly transformed cells. RESULTS: The expression of tankyrase in malignantly transformed cells was higher than that in normal cells. CONCLUSION: The overexpression of tankyrase in cell transformation might be related to the carcinogenesis of crystalline nickel sulfide.

Key words: crystalline nickel sulfide, human bronchial epithelial cells, transformed cells, tumor cells, tankyrase

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